Издательский дом "Заславский"

Журнал «Боль. Суставы. Позвоночник» Том 14, №3, 2024

Українські рекомендації щодо профілактики та лікування глюкокортикоїд-індукованого остеопорозу

Авторы: Григор’єва Н.В. (1), Коваленко В.М. (2), Корж М.О. (3, 4), Тронько М.Д. (5), Головач І.Ю. (6), Дєдух Н.В. (1), Рекалов Д.Г. (2), Страфун С.С. (7), Сміян С.І. (8), Голубовська О.А. (9), Дзюблик Я.О. (10), Харченко Н.В. (11), Проценко Г.О. (2), Гарміш О.О. (2), Орленко В.Л. (5), Климовицький Ф.В. (12), Мусієнко А.С. (1), Карасевська Т.А. (9), Українська асоціація остеопорозу
(1) - Державна установа «Інститут геронтології імені Д.Ф. Чеботарьова Національної академії медичних наук України», м. Київ, Україна
(2) - Державна установа «Національний науковий центр «Інститут кардіології, клінічної та регенеративної медицини імені академіка М.Д. Стражеска Національної академії медичних наук України», м. Київ, Україна
(3) - Державна установа «Інститут патології хребта та суглобів імені проф. М.І. Ситенка Національної академії медичних наук України», м. Харків, Україна
(4) - Харківський національний медичний університет Міністерства охорони здоров’я України, м. Харків, Україна
(5) - Державна установа «Інститут ендокринології та обміну речовин імені В.П. Комісаренка Національної академії медичних наук України», м. Київ, Україна
(6) - Клінічна лікарня «Феофанія» Державного управління справами, м. Київ, Україна
(7) - Державна установа «Інститут травматології та ортопедії Національної академії медичних наук України», м. Київ, Україна
(8) - Тернопільський національний медичний університет імені І.Я. Горбачевського Міністерства охорони здоров’я України, м. Тернопіль, Україна
(9) - Національний медичний університет імені О.О. Богомольця Міністерства охорони здоров’я України, м. Київ, Україна
(10) - Державна установа «Національний інститут фтизіатрії і пульмонології імені Ф.Г. Яновського Національної академії медичних наук України», м. Київ, Україна
(11) - Національний університет охорони здоров’я України імені П.Л. Шупика, м. Київ, Україна
(12) - Донецький національний медичний університет Міністерства охорони здоров’я України, м. Кропивницький, Україна
Рубрики: Ревматология, Травматология и ортопедия
Разделы: Справочник специалиста

Резюме

Вступ. Глюкокортикоїд-індукований остеопороз (ГК-ОП) — метаболічне захворювання кісткової тканини, що розвивається внаслідок прийому глюкокортикоїдів (ГК), є однією з найбільш частих причин вторинного остеопорозу, призводить до збільшення ризику малотравматичних переломів, збільшення інвалідизації хворих та їх смертності. Незважаючи на проведені поодинокі дослідження в Україні щодо епідеміології та лікування ГК-ОП, національних рекомендацій щодо його менеджменту до цього часу не було, що й стало підставою для їх створення. Мета дослідження: на основі аналітичного аналізу сучасних літературних джерел розробити національні рекомендації щодо діагностики, профілактики та лікування ГК-ОП задля поліпшення обізнаності медичної спільноти України, поліпшення менеджменту і зменшення соціально-економічного тягаря захворювання. Матеріали та методи. Для розробки рекомендацій була створена група з 18 експертів, провідних українських учених різного фаху. Проведено аналіз сучасних літературних джерел щодо епідеміології, факторів ризику, діагностики, профілактики й лікування ГК-ОП, моніторингу ефективності й безпечності його лікування. Синтез доказів виконано за допомогою системи GRADE, критичну оцінку якості положень рекомендацій проведено за допомогою інструменту AGREE II. Результати. Рекомендації складаються з 12 положень щодо скринінгу, діагностики, профілактики й лікування ГК-ОП. Авторами наголошено на необхідності збільшення обізнаності медичної спільноти України щодо проблеми, а також пацієнтів щодо можливих побічних ефектів ГК, подано особливості клінічної оцінки ризику остеопоротичних переломів у користувачів ГК, а також сучасні й доступні в Україні методи його діагностики та лікування. Висновки. Перші українські рекомендації щодо скринінгу, діагностики, профілактики та лікування ГК-ОП є важливим національним інструментом менеджменту ГК-ОП, який рекомендований Президією Української асоціації остеопорозу до використання в практичній охороні здоров’я лікарями різного фаху.

Ключевые слова

глюкокортикоїд-індукований остеопороз; вторинний остеопороз; рекомендації; діагностика, профілактика, лікуввання

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